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Empowering Reproducibility in Cell Culture

Meet the low-cost standard for hypoxic environment cell culture that enabled Nobel Prize-winning research

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A model is only as good as its ability to replicate the natural environment.

Originally founded in 1973 as Billups-Rothenberg, Inc., Embrient’s mission is to improve scientific discovery and reproducibility across diverse areas of research, including stem cells, organoids, immunology, tumor biology, IVF, infectious diseases, and hypoxia/hyperoxia.

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Physioxia for Cell Culture

If you’ve worked with cell cultures, you’re probably familiar with the term ‘normoxia,’ which refers to the standard 21% oxygen level used in many labs. But did you know that most cells in the human body actually experience much lower oxygen levels, typically between 1 to 8%? This is called ‘physioxia,’ or physiologic oxygen. This video explores why mimicking these conditions can significantly improve your cell culture outcomes.

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Studies clearly show that cells cultured under appropriate physiological conditions express regulator genes in vivo that are silent under normoxic (21% O2) concentration.

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Thousands of papers have cited our incubator products and accessories across a diverse span of research areas. Don’t let your research fall behind because of the wrong cell culture conditions for your cells!

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Explore the differences in neuronal cell behavior under low oxygen (physiological) compared to atmospheric oxygen conditions and gain insights into optimizing neuronal cell culture systems.

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Explore the importance of hypoxia in stem cell culture, the molecular pathways involved, and its implications for optimizing stem cell applications.

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A quick summary on the latest key points for malaria research and discovery.

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Discover how the hypoxic tumor microenvironment fuels cancer growth.


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Check out our table summarizing data on published physioxic conditions tested for various cell lines and primary cells and the experimental outcomes.

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The answer is: never. Learn more about why.



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