Empowering Reproducibility in Cell Culture

Over fifty years of enabling hypoxia research and discovery

Embrient, formerly Billups-Rothenberg, Inc., continues the mission to provide the most effective incubator solutions with the highest reproducibility that matches physiological environments for culturing cells to advance scientific discovery.

While many recognize the importance of the 2019 Nobel Prize Award-winning research on HIF-1α and hypoxic/physiologic effects on cells, a large majority of cell culture experimentation continues to be performed at atmospheric oxygen levels, which is not optimal for cell culture. Embrient research products are engineered to support hypoxic/physioxic cell culture to enable optimized cell research, expansion, and engineering conditions. Our simple-to-use, low-cost products provide effective solutions for modeling the hypoxic tumor microenvironment or rapidly adapting physiologic conditions for your cell biology, IVF, and organoid environment. The portfolio of high-quality products provides a complete complement of tools to get started or expand your research using hypoxic conditions.

Illustration from NIH BIOART Source.

The Modular Incubator Chamber (MIC-101) is in use world-wide to customize tissue culture conditions for gas mixture and temperature. This air-tight chamber has been proven safe and reliable for IVF, stem cells, malaria research and the culturing of a host of cell lines. The MIC-101 has become the gold standard for culturing in hypoxia. Each unit is a self-contained incubator enabling you to create the desired tissue culture environment (gas concentration and humidity).

The Single Flow Meter (SFM-3001) and the Dual Flow Meter (DFM-3002) are affordable, simple to use devices that seamlessly integrate with the Modular Incubator Chamber (MIC-101) system allowing investigators to precisely gauge when they’ve achieved a full exchange of gases within their chamber, making experiments more accurate and reliable. The flow meters can be adjusted for optimal flow rates between 3 and 50 L/min (Max 50 L/min).

Eliminate [35S]-Met/Cys Contamination! The Hot Box System captures nearly 100% of radioactive gases. Simple and inexpensive to use, the system consists of the Modular Incubator Chamber (MIC-101) and Hot Filters, designed to contain and irreversibly bind [35S] volatiles.

Conveniently order accessory products, such as air filters, clamps, and tubing, or replacement parts for your existing Modular Incubator Chamber. Also find
conversion kits to convert your Modular Incubator Chamber into a Hot Box System.


The GMS-5003 is a state-of-the-art flow-through oxygen (O2) sensor that delivers rapid and precise oxygen readings from 0% to 25%. It is optimized for use with our Dual Flow Meter (DFM-3002) to mix gases, creating customized hypoxic culture conditions within the MIC-101 Modular Incubator Chamber.


Get your custom oxygen cell culture environment up and running fast with our bundles. Find the best option for your needs and save.